I just updated my mysql installation from 5.0.27 to 5.0.45 (windows xp) and my server would not start.
I looked in the error log: "mysql Page directory corruption: supremum not pointed to"
I searched the net, nothing. I then compared my my.ini files and foudn the problem: the idiotic update removed my datafile (I’m not sure if it was me re-configuring the server)
in any case, just pay attention when updating 🙂